Motif ID: FOX{C1,C2}.p2

Z-value: 0.403


Transcription factors associated with FOX{C1,C2}.p2:

Gene SymbolEntrez IDGene Name
FOXC1 2296 forkhead box C1
FOXC2 2303 forkhead box C2 (MFH-1, mesenchyme forkhead 1)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
FOXC2chr16_+_866008560.383.5e-01Click!
FOXC1chr6_+_16106800.049.2e-01Click!


Activity profile for motif FOX{C1,C2}.p2.

activity profile for motif FOX{C1,C2}.p2


Sorted Z-values histogram for motif FOX{C1,C2}.p2

Sorted Z-values for motif FOX{C1,C2}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOX{C1,C2}.p2

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image


Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_+_189839132 0.488 COL3A1
collagen, type III, alpha 1
chr2_+_189839078 0.476 NM_000090
COL3A1
collagen, type III, alpha 1
chr2_+_189839113 0.396 COL3A1
collagen, type III, alpha 1
chr2_-_158300517 0.358 NM_004288
CYTIP
cytohesin 1 interacting protein
chr3_+_45927995 0.324 NM_006641
NM_031200
CCR9

chemokine (C-C motif) receptor 9

chr6_+_47624222 0.254 NM_153839
GPR111
G protein-coupled receptor 111
chr22_+_31003069 0.247 NM_000355
NM_001184726
TCN2

transcobalamin II

chr3_-_149095413 0.226 TM4SF1
transmembrane 4 L six family member 1
chr3_-_149095333 0.215 TM4SF1
transmembrane 4 L six family member 1
chr14_+_29236882 0.212 FOXG1
forkhead box G1
chr1_+_163038934 0.208 NM_001113381
RGS4
regulator of G-protein signaling 4
chr2_-_188419049 0.197 TFPI
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr2_+_33359607 0.176 NM_000627
NM_001166264
NM_001166265
NM_001166266
LTBP1



latent transforming growth factor beta binding protein 1



chr3_-_149095458 0.167 TM4SF1
transmembrane 4 L six family member 1
chr2_-_216300444 0.155 FN1
fibronectin 1
chr11_-_2156721 0.154 IGF2
insulin-like growth factor 2 (somatomedin A)
chr14_+_51026742 0.147 NM_015915
NM_181598
ATL1

atlastin GTPase 1

chr17_-_10741398 0.145 NM_001101387
PIRT
phosphoinositide-interacting regulator of transient receptor potential channels
chr11_-_59633942 0.132 NM_001062
TCN1
transcobalamin I (vitamin B12 binding protein, R binder family)
chrX_+_70521627 0.124 NM_012278
ITGB1BP2
integrin beta 1 binding protein (melusin) 2
chr1_-_202129731 0.118 PTPN7
protein tyrosine phosphatase, non-receptor type 7
chr12_-_56236614 0.118 NM_002429
MMP19
matrix metallopeptidase 19
chr5_+_140797243 0.118 NM_018927
PCDHGB7
protocadherin gamma subfamily B, 7
chr14_+_76071804 0.117 NM_001195283
FLVCR2
feline leukemia virus subgroup C cellular receptor family, member 2
chr11_-_133715368 0.111 NM_174927
SPATA19
spermatogenesis associated 19
chr2_-_188419185 0.109 NM_001032281
NM_006287
TFPI

tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)

chr5_+_173472737 0.108 HMP19
HMP19 protein
chr13_-_26625164 0.107 NM_001007538
SHISA2
shisa homolog 2 (Xenopus laevis)
chr3_-_100712248 0.107 NM_015429
ABI3BP
ABI family, member 3 (NESH) binding protein
chr11_+_118175294 0.106 NM_000733
CD3E
CD3e molecule, epsilon (CD3-TCR complex)
chr1_-_168698412 0.105 NM_001937
DPT
dermatopontin
chrX_+_138612894 0.102 NM_000133
F9
coagulation factor IX
chr7_-_23571443 0.098 NM_013293
TRA2A
transformer 2 alpha homolog (Drosophila)
chr7_+_104681378 0.096 MLL5
myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
chr18_-_65182507 0.096 DSEL
dermatan sulfate epimerase-like
chr12_+_53645369 0.095 NM_001170790
MFSD5
major facilitator superfamily domain containing 5
chr7_-_92747269 0.095 SAMD9
sterile alpha motif domain containing 9
chrX_-_130423199 0.094 IGSF1
immunoglobulin superfamily, member 1
chr5_+_304290 0.094 NM_001242412
NM_020731
AHRR

aryl-hydrocarbon receptor repressor

chr5_+_140710203 0.088 NM_018912
NM_031993
PCDHGA1

protocadherin gamma subfamily A, 1

chr5_+_156820161 0.087 CYFIP2
cytoplasmic FMR1 interacting protein 2
chr14_+_95047758 0.084 SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr17_-_67311773 0.082 NM_018672
ABCA5
ATP-binding cassette, sub-family A (ABC1), member 5
chr14_+_51026853 0.082 ATL1
atlastin GTPase 1
chr17_+_48821106 0.081 LUC7L3
LUC7-like 3 (S. cerevisiae)
chr11_+_15136483 0.079 NM_001042536
INSC
inscuteable homolog (Drosophila)
chr7_-_92747317 0.079 NM_001193307
NM_017654
SAMD9

sterile alpha motif domain containing 9

chr12_+_52306112 0.076 NM_001077401
ACVRL1
activin A receptor type II-like 1
chr11_+_65271145 0.076


chr5_+_140474198 0.075 NM_018936
PCDHB2
protocadherin beta 2
chr17_-_64225496 0.074 NM_000042
APOH
apolipoprotein H (beta-2-glycoprotein I)
chr2_-_202563353 0.071 NM_033066
MPP4
membrane protein, palmitoylated 4 (MAGUK p55 subfamily member 4)
chr14_+_101295409 0.069 MEG3
maternally expressed 3 (non-protein coding)
chr8_+_54793516 0.069 RGS20
regulator of G-protein signaling 20
chr11_+_120973374 0.069 NM_005422
TECTA
tectorin alpha
chr18_-_56296188 0.068 NM_052947
ALPK2
alpha-kinase 2
chr7_-_55930444 0.068 NM_207366
SEPT14
septin 14
chr2_-_192015733 0.068 STAT4
signal transducer and activator of transcription 4
chr1_-_157670280 0.067 NM_052939
FCRL3
Fc receptor-like 3
chr9_+_140145712 0.066 NM_001004353
C9orf173
chromosome 9 open reading frame 173
chr9_-_132515290 0.062 NM_004878
PTGES
prostaglandin E synthase
chr5_+_71502700 0.062 MAP1B
microtubule-associated protein 1B
chr10_+_7745284 0.062 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr10_+_7745341 0.061 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr5_+_140734767 0.061 NM_018917
NM_032053
PCDHGA4

protocadherin gamma subfamily A, 4

chr13_-_20346398 0.061 PSPC1
paraspeckle component 1
chr16_-_21222867 0.060 NM_003460
ZP2
zona pellucida glycoprotein 2 (sperm receptor)
chr6_+_158438079 0.057 NM_001178088
SYNJ2
synaptojanin 2
chr10_+_7745325 0.057 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr2_+_121554866 0.056 NM_005270
GLI2
GLI family zinc finger 2
chr3_-_52713728 0.056 NM_018165
NM_181042
PBRM1

polybromo 1

chr14_+_95047730 0.055 NM_000624
SERPINA5
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
chr1_+_181003143 0.054 MR1
major histocompatibility complex, class I-related
chr2_-_158731622 0.054 NM_001105
ACVR1
activin A receptor, type I
chr11_-_114430579 0.054 NM_152315
FAM55A
family with sequence similarity 55, member A
chr11_-_111742205 0.054 NM_001077690
NM_024740
ALG9

asparagine-linked glycosylation 9, alpha-1,2-mannosyltransferase homolog (S. cerevisiae)

chr10_+_7745354 0.054 ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr1_-_162381805 0.052 NM_053282
SH2D1B
SH2 domain containing 1B
chr3_-_69037498 0.052 C3orf64
chromosome 3 open reading frame 64
chr19_+_48828820 0.052 EMP3
epithelial membrane protein 3
chr3_+_196366637 0.052 LRRC33
leucine rich repeat containing 33
chr4_+_186131283 0.051 NM_031953
SNX25
sorting nexin 25
chr1_-_54199876 0.050 NM_147193
GLIS1
GLIS family zinc finger 1
chr3_+_118892363 0.050 NM_006952
UPK1B
uroplakin 1B
chr16_+_78062985 0.049 NM_001244755
CLEC3A
C-type lectin domain family 3, member A
chr7_-_92848837 0.049 NM_198151
HEPACAM2
HEPACAM family member 2
chr1_+_40735749 0.048 ZMPSTE24
zinc metallopeptidase (STE24 homolog, S. cerevisiae)
chr17_+_26646120 0.048 NM_014573
TMEM97
transmembrane protein 97
chr1_-_231114580 0.047 TTC13
tetratricopeptide repeat domain 13
chr12_+_72332625 0.047 NM_173353
TPH2
tryptophan hydroxylase 2
chr17_-_7082654 0.047 NM_001197216
NM_001671
ASGR1

asialoglycoprotein receptor 1

chr5_+_140797270 0.046 PCDHGB7
protocadherin gamma subfamily B, 7
chr3_+_127634317 0.046 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr3_-_164914448 0.046 NM_014926
SLITRK3
SLIT and NTRK-like family, member 3
chr12_-_46633551 0.046 SLC38A1
solute carrier family 38, member 1
chr10_+_7745229 0.046 NM_002216
ITIH2
inter-alpha-trypsin inhibitor heavy chain 2
chr12_+_32654976 0.046 NM_139241
FGD4
FYVE, RhoGEF and PH domain containing 4
chr21_+_31768294 0.045 NM_181599
KRTAP13-1
keratin associated protein 13-1
chr1_+_171481164 0.044 PRRC2C
proline-rich coiled-coil 2C
chr7_-_107880492 0.044 NM_001037132
NRCAM
neuronal cell adhesion molecule
chr6_+_30908776 0.044 NM_080870
DPCR1
diffuse panbronchiolitis critical region 1
chr15_-_90349819 0.043 ANPEP
alanyl (membrane) aminopeptidase
chr4_+_160188997 0.043 NM_014247
RAPGEF2
Rap guanine nucleotide exchange factor (GEF) 2
chr17_+_8214139 0.043 NM_025014
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr6_-_15663098 0.042 DTNBP1
dystrobrevin binding protein 1
chr3_-_149095517 0.042 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr21_-_43735462 0.042 TFF3
trefoil factor 3 (intestinal)
chr13_-_99959649 0.040 NM_004951
GPR183
G protein-coupled receptor 183
chr18_+_32335939 0.040 NM_001390
NM_001391
DTNA

dystrobrevin, alpha

chr3_+_98250742 0.040 NM_005290
GPR15
G protein-coupled receptor 15
chr1_+_111772332 0.040 NM_001025199
CHI3L2
chitinase 3-like 2
chr11_-_13517525 0.039 NM_000315
PTH
parathyroid hormone
chr5_+_126984712 0.038 NM_001048252
CTXN3
cortexin 3
chr17_+_19976828 0.038 SPECC1
sperm antigen with calponin homology and coiled-coil domains 1
chr10_+_90424145 0.038 NM_001198828
NM_001198829
NM_001198830
NM_004190
LIPF



lipase, gastric



chr4_+_39063851 0.038 NM_015990
NM_199039
KLHL5

kelch-like 5 (Drosophila)

chr5_+_112043188 0.038 NM_001127511
APC
adenomatous polyposis coli
chr10_+_124670216 0.037 NM_001029888
FAM24A
family with sequence similarity 24, member A
chr12_-_57634474 0.037 NM_020142
NDUFA4L2
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
chr17_-_7082559 0.036 ASGR1
asialoglycoprotein receptor 1
chr17_-_39093671 0.036 NM_015515
KRT23
keratin 23 (histone deacetylase inducible)
chr10_-_98325100 0.035 TM9SF3
transmembrane 9 superfamily member 3
chr1_+_62902653 0.035 USP1
ubiquitin specific peptidase 1
chr19_-_33462791 0.035 NM_032816
CEP89
centrosomal protein 89kDa
chr6_+_155538096 0.034 NM_001010927
TIAM2
T-cell lymphoma invasion and metastasis 2
chr1_-_24239758 0.034 NM_001841
CNR2
cannabinoid receptor 2 (macrophage)
chr1_-_159825136 0.034 NM_001134233
C1orf204
chromosome 1 open reading frame 204
chr14_+_24779356 0.033 NM_001164692
NM_019839
LTB4R2

leukotriene B4 receptor 2

chr6_+_132873829 0.033 NM_053278
TAAR8
trace amine associated receptor 8
chr5_-_32403310 0.033 ZFR
zinc finger RNA binding protein
chr4_+_186350543 0.032 NM_001114357
C4orf47
chromosome 4 open reading frame 47
chr1_+_8384389 0.031 NM_001080397
SLC45A1
solute carrier family 45, member 1
chr4_+_88754120 0.031 NM_001184695
NM_001184696
NM_001184697
NM_020203
MEPE



matrix extracellular phosphoglycoprotein



chr20_+_17680592 0.031 NM_001014977
NM_178477
BANF2

barrier to autointegration factor 2

chr6_+_12717036 0.031 NM_001242648
NM_030948
PHACTR1

phosphatase and actin regulator 1

chr16_-_72206023 0.030 NM_031293
PMFBP1
polyamine modulated factor 1 binding protein 1
chr2_+_241938254 0.030 NM_001080437
SNED1
sushi, nidogen and EGF-like domains 1
chr1_-_120612019 0.030 NOTCH2
notch 2
chr13_-_110802708 0.030 COL4A1
collagen, type IV, alpha 1
chr16_+_69680959 0.030 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr10_+_43633880 0.030 NM_018590
CSGALNACT2
chondroitin sulfate N-acetylgalactosaminyltransferase 2
chr5_-_156593178 0.030 NM_130899
FAM71B
family with sequence similarity 71, member B
chr5_-_160279045 0.030 NM_025153
ATP10B
ATPase, class V, type 10B
chr11_-_61124223 0.030 NM_001161452
CYBASC3
cytochrome b, ascorbate dependent 3
chr15_+_91769329 0.029 SV2B
synaptic vesicle glycoprotein 2B
chr2_-_88285308 0.029 NM_001024457
RGPD1
RANBP2-like and GRIP domain containing 1
chr8_-_117023 0.029 NM_001005504
OR4F21
olfactory receptor, family 4, subfamily F, member 21
chrM_+_9725 0.029


chr12_-_71031174 0.029 NM_001109754
PTPRB
protein tyrosine phosphatase, receptor type, B
chr8_+_37654833 0.029 GPR124
G protein-coupled receptor 124
chr3_-_151987332 0.029 LOC401093
uncharacterized LOC401093
chr17_+_73472578 0.028 KIAA0195
KIAA0195
chr20_-_6034617 0.028 NM_152611
LRRN4
leucine rich repeat neuronal 4
chr3_-_13057130 0.028


chr7_+_31003635 0.027 NM_000823
GHRHR
growth hormone releasing hormone receptor
chr3_+_108541544 0.027 NM_016388
TRAT1
T cell receptor associated transmembrane adaptor 1
chr17_-_53800074 0.027 NM_018286
TMEM100
transmembrane protein 100
chr1_+_27719151 0.027 NM_005281
GPR3
G protein-coupled receptor 3
chr2_-_233641225 0.027 NM_001172416
NM_001172417
NM_002242
KCNJ13


potassium inwardly-rectifying channel, subfamily J, member 13


chr6_-_155777036 0.026 NM_015718
NOX3
NADPH oxidase 3
chr12_+_25205488 0.026 LRMP
lymphoid-restricted membrane protein
chr6_-_41122025 0.026 NM_178174
TREML1
triggering receptor expressed on myeloid cells-like 1
chr3_+_97868169 0.025 NM_001005514
OR5H14
olfactory receptor, family 5, subfamily H, member 14
chr19_+_8509859 0.025 HNRNPM
heterogeneous nuclear ribonucleoprotein M
chr16_+_69600110 0.025 NFAT5
nuclear factor of activated T-cells 5, tonicity-responsive
chr8_-_109799769 0.025 NM_153015
TMEM74
transmembrane protein 74
chr17_-_46507481 0.025 NM_001075099
NM_003726
SKAP1

src kinase associated phosphoprotein 1

chr7_+_74188308 0.025 NM_000265
NCF1
NCF1B
neutrophil cytosolic factor 1
neutrophil cytosolic factor 1B pseudogene
chr13_+_52436116 0.024 NM_031290
CCDC70
coiled-coil domain containing 70
chr6_-_152702329 0.024 SYNE1
spectrin repeat containing, nuclear envelope 1
chr7_+_134832765 0.024 NM_018295
TMEM140
transmembrane protein 140
chr14_+_64971504 0.024 ZBTB1
zinc finger and BTB domain containing 1
chr2_+_177016112 0.024 NM_014621
HOXD4
homeobox D4
chr20_+_54967405 0.024 NM_001033521
CSTF1
cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa
chrX_+_26156459 0.024 NM_173699
MAGEB18
melanoma antigen family B, 18
chr2_-_175260349 0.024 NM_004882
CIR1
corepressor interacting with RBPJ, 1
chr3_-_194090459 0.024 NM_001135057
NM_130830
LRRC15

leucine rich repeat containing 15

chr9_-_116861506 0.023 KIF12
kinesin family member 12
chr2_-_127963342 0.023 NM_001001665
CYP27C1
cytochrome P450, family 27, subfamily C, polypeptide 1
chr7_+_99955625 0.023 NM_178238
PILRB
paired immunoglobin-like type 2 receptor beta
chr5_-_39424930 0.023 DAB2
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
chr9_-_113100076 0.023 NM_001003936
TXNDC8
thioredoxin domain containing 8 (spermatozoa)
chr6_+_7108184 0.022 RREB1
ras responsive element binding protein 1
chr1_+_62902735 0.022 USP1
ubiquitin specific peptidase 1
chr1_+_153600859 0.022 NM_006271
S100A1
S100 calcium binding protein A1
chr2_+_102927961 0.022 NM_016232
IL18R1
IL1RL1
interleukin 18 receptor 1
interleukin 1 receptor-like 1
chr4_+_71494460 0.022 NM_031889
ENAM
enamelin
chr14_-_54908035 0.022 NM_005776
CNIH
cornichon homolog (Drosophila)
chr1_-_231114596 0.022 TTC13
tetratricopeptide repeat domain 13
chr6_-_15663260 0.022 NM_032122
NM_183040
DTNBP1

dystrobrevin binding protein 1

chr9_-_115480363 0.021 NM_021218
C9orf80
chromosome 9 open reading frame 80
chr17_-_39092714 0.021 KRT23
keratin 23 (histone deacetylase inducible)
chr16_+_29831755 0.021 MVP
major vault protein
chr1_+_152691997 0.021 NM_001024679
C1orf68
chromosome 1 open reading frame 68
chr9_-_115480319 0.021 C9orf80
chromosome 9 open reading frame 80
chr19_-_49116693 0.021 NM_017708
FAM83E
family with sequence similarity 83, member E
chr12_-_68619535 0.021 NM_018402
IL26
interleukin 26
chr21_-_36421195 0.020 RUNX1
runt-related transcription factor 1
chr20_-_33460558 0.020 NM_178026
GGT7
gamma-glutamyltransferase 7
chr3_+_184033936 0.020 EIF4G1
eukaryotic translation initiation factor 4 gamma, 1

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
1.86 4.10e-02 GO:0002376 immune system process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
1.74 3.03e-04 GO:0005576 extracellular region
2.10 3.97e-04 GO:0044421 extracellular region part
3.03 1.72e-03 GO:0005578 proteinaceous extracellular matrix
2.69 6.70e-03 GO:0031012 extracellular matrix
1.35 4.71e-02 GO:0071944 cell periphery

Gene overrepresentation in function category:

enrichment   p-value GO term description
22.05 5.74e-03 GO:0016175 superoxide-generating NADPH oxidase activity
7.72 9.70e-03 GO:0003823 antigen binding